Foreword by Professor Sir James Armour.
1. Nematode parasites.
The important nematode genera and species parasitising ruminant livestock.
Small intestinal genera.
Large intestinal genera.
The transition to parasitism.
The dauer larva.
The nematode life cycle.
Niches occupied by parasitic nematodes within the vertebrate host.
The lifespan of parasitic nematodes.
2. Pathophysiology of nematode infections.
Are parasites always harmful?
The small intestine.
The large intestine.
The impact of parasites on overall gut function.
Effects beyond the gut.
3. Epidemiology of gastrointestinal nematodes in grazing ruminants.
Ecology of GINs – pasture.
Egg to L3 development.
Effect of host.
Survival of L3.
Translation of infective larvae.
Grazing behaviour and the avoidance of parasites.
Patterns of infection.
Overdispersion of parasites.
Epidemiology of ‘parasitism’.
An increase in the infective mass.
Alteration in the susceptibility of stock.
Arrested development and hypobiosis.
Introduction of susceptible stock onto an infected area.
Insufficient age-related immunity.
The introduction of infected stock to a clean environment.
Epidemiology of cattle parasites.
Population biology in the parasitic phase.
4. The principles of gastrointestinal nematode control.
Control of parasites with anthelmintic drenches.
Strategic drenching programmes.
Principles of worm control in cattle.
Control of GIN by grazing management.
Alternate/mixed grazing with different host species or stock classes.
Resistance to treatment.
What are anthelmintics?
How effective does an anthelmintic have to be?
Which species does an anthelmintic against GIN need to remove?
Description, efficacy, profile and mode of action of anthelmintic families.
Combination of anthelmintic treatments.
Modifying the delivery of anthelmintics.
Controlled release of anthelmintics.
6. Anthelmintic resistance.
Evolution of anthelmintic resistance.
Worldwide occurrence of anthelmintic resistance.
Resistance to one or more active families by one or more species.
Impact of resistance on productivity.
Mechanisms of resistance.
Inheritance of resistance.
Detection of resistance.
7. Drenching and resistance.
Frequency of treatment.
Why use persistent drenches?
The provision of safe pasture and resistance.
Persistence and efficacy.
Therapeutic efficacy and resistance – ‘head selection’.
Prophylactic efficacy and resistance – ‘tail selection’.
Heads or tails?
Persistent activity, immunity and resistance.
Persistent activity, density dependence and resistance.
Controlling resistance by drench rotation.
Drench rotation within seasons.
Modelling drench rotation.
Removing resistant worm burdens.
Efficacy of single actives vs. combinations.
The odds are against multiple mutations.
Resistance is already present to one or more constituent active.
8. Worm control and resistance management.
What is refugia?
Why do we need refugia?
How to produce and utilise refugia.
Importation of resistant parasites.
A twin approach to worm control and resistance management – utilising refugia and combination drenches.
9. ‘Non-chemical’ control options.
PSM as anthelmintics.
Practical applicability on-farm.
Other anthelmintic plants.
10. Nutrition and parasitism.
Metabolic cost of parasitism.
Metabolic cost of infection.
Metabolic costs of immunity.
Parasites and nutrition: a nutrient utilisation framework.
Supplementation for increased resilience to parasites.
Supplementation for increased resistance to parasites.
Undernutrition and parasitism.
Micronutrients and parasitism.
Improving nutrient availability.
Forage plants and parasitism.
Supplementation and immunity: increasing or enabling?
11. Animal genetics and parasitism.
Resistance vs. productivity.
Pasture contamination, resistance and resilience.
Markers for resistance and resilience.
Genetics, worm control and resistance management.
12. The immune response to parasites.
Evolution of the host–parasite relationship.
Immunity and GIN population dynamics.
The immune phenotype.
Components of host responses to GI parasites.
Adaptive immune responses to GINs.
The anti-GIN immune response in cattle to O. ostertagi.
Impact of immunity on parasites.
Utilising immune responses to control GIN.
What next for immunoparasitology research?