About the Authors xi
Preface xiii
About the Companion Web Site xv
1 Introduction to Laboratory Animal Medicine 1
Animals Used in Research, Product Safety Testing, and Education 2
Ethical Considerations 5
Organizations 9
References 14
Further Reading 14
Chapter 1 Review 15
2 Regulations, Policies, and Principles Governing the Care and Use of Laboratory Animals 18
Animal Welfare Act and Regulations 18
References 31
Further Reading 32
Chapter 2 Review 32
3 Facility Design, Equipment, Housing, and Management 34
Laboratory Animal Facility Design 34
Biosecurity 35
Facility Equipment 41
Housing 43
Management 48
References 50
Further Reading 50
Chapter 3 Review 51
4 Mice 54
Genetics 54
Microbiologic Classifications 56
Uses 57
Behavior 57
Anatomic and Physiologic Features 58
Breeding and Reproduction 60
Husbandry 61
Techniques 66
Special Techniques: Transgenic Production Technology 76
Therapeutic Agents 80
Introduction to Diseases of Mice 80
References 94
Further Reading 97
Chapter 4 Review 102
5 Rats 105
Genetics 105
Microbiologic Classifications 106
Uses 107
Behavior 107
Anatomic and Physiologic Features 108
Breeding and Reproduction 110
Husbandry 110
Techniques 113
Therapeutic Agents 123
Introduction to Diseases of Rats 123
References 138
Further Reading 140
Chapter 5 Review 143
6 Gerbils 145
Uses 145
Behavior 146
Anatomic and Physiologic Features 146
Breeding and Reproduction 147
Husbandry 148
Techniques 149
Therapeutic Agents 156
Introduction to Diseases of Gerbils 156
References 161
Further Reading 163
Chapter 6 Review 164
7 Hamsters 167
Uses 167
Behavior 168
Anatomic and Physiologic Features 169
Breeding and Reproduction 171
Husbandry 172
Techniques 173
Therapeutic Agents 179
Introduction to Diseases of Hamsters 182
References 189
Further Reading 190
Chapter 7 Review 192
8 Guinea Pigs 195
Uses 195
Behavior 196
Anatomic and Physiologic Features 197
Breeding and Reproduction 200
Husbandry 201
Techniques 202
Therapeutic Agents 208
Introduction to Diseases of Guinea Pigs 208
References 221
Further Reading 223
Chapter 8 Review 225
9 Chinchillas 227
Uses 227
Behavior 228
Anatomic and Physiologic Features 228
Breeding and Reproduction 230
Husbandry 231
Techniques 232
Therapeutic Agents 237
Introduction to Diseases of Chinchillas 239
References 244
Further Reading 245
Chapter 9 Review 246
10 Rabbits 249
Breeds 249
Uses 250
Behavior 251
Anatomic and Physiologic Features 251
Breeding and Reproduction 254
Husbandry 256
Techniques 259
Therapeutic Agents 271
Introduction to Diseases of Rabbits 271
References 289
Further Reading 292
Chapter 10 Review 295
11 Ferrets 298
Uses 298
Behavior 299
Anatomic and Physiologic Features 299
Breeding and Reproduction 301
Husbandry 302
Techniques 304
Therapeutic Agents 312
Introduction to Diseases of Ferrets 312
References 330
Further Reading 332
Chapter 11 Review 334
12 Primates 337
Taxonomy 337
Uses 341
Behavior 342
Anatomic and Physiologic Features 343
Breeding and Reproduction 344
Husbandry 345
Techniques 349
Therapeutic Agents 356
Introduction to Diseases of Nonhuman Primates 356
References 377
Further Reading 379
Chapter 12 Review 383
13 Research Variables and Quality Control 386
Research Variables: Intrinsic and Extrinsic Factors 386
Quality Control 395
Reference 400
Further Reading 400
Chapter 13 Review 401
Appendix 1: Normal Values 403
Appendix 2: Comparative Biologic and Reproductive Values by Species 408
Appendix 3: Supportive and Critical Care Products for Laboratory Animal Use 412
Answers to Review Questions 414
Index 417