Cover image
Title page
Table of Contents
Copyright
Dedication
Acknowledgments
Preface
List of Tables
List of Illustrations
Section 1. Basic Science
1. The immune system and the defense of the body
Innate immunity
Adaptive immunity
Suggested reading
2. Type 2 immune responses
Dendritic cells
Helper T cells
Regulatory T cells
Innate lymphoid cells
Type 2 responses
B cell responses
Immunoglobulin E
Suggested reading
3. Mast cells
Life history
Structure
Location
Receptors
Secretory granules
Degranulation
Non-IgE-mediated degranulation
Late-phase responses
Suggested reading
4. Eosinophils and basophils
Eosinophils
Basophils
Suggested reading
5. The mediators of inflammation and allergy
Inflammatory mediators
Cytokines
Suggested reading
6. The itch-scratch cycle
Itch sensation
Itch mediators
Non-histaminergic itch
Cells involved
Scratching
Suggested reading
7. The hygiene hypothesis
The hygiene hypothesis
The intestinal microbiota
Microbial immunosuppression
Dysbiosis
Skin microbiota
Respiratory microbiota
Helminth parasites
Suggested reading
Section 2. Allergic Diseases
8. Anaphylaxis
IgE-dependent anaphylaxis
Non-IgE-mediated anaphylaxis
Domestic mammal anaphylaxis
Suggested readings
9. Atopic dermatitis
Introduction
Predisposing conditions
Allergic inflammation
Pathogenesis
Clinical disease
Feline atopic skin syndrome
Suggested readings
10. Malassezia and staphylococci
Malassezia
Staphylococci
Suggested readings
11. Allergies in the gastrointestinal tract
The fate of foods
Food allergic animals
Milk allergy in cattle
Parasite “self-cure”
Suggested readings
12. Allergies to arthropods
Chitin responses
Inhalant allergies
Allergies to insect venoms
Suggested readings
13. Allergic respiratory disease
Asthma in humans
Respiratory allergies in animals
Suggested readings
14. Drug allergies
Allergic responses
Immune receptor interactions
Pseudoallergic reactions
Some specific drugs
Management
Suggested readings
15. Allergies to vaccines
Type I hypersensitivities
Type II hypersensitivities
Type III hypersensitivities
Type IV reactions
Suggested readings
Section 3. Treatments
16. Allergen-specific immunotherapy
The science of immunotherapy
Suggested readings
17. Drug therapy
Inhibition of mast cell products
Epidermal barrier dysfunction
Other treatments
Biological therapy
Suggested readings
Section 4. Other Hypersensitivities
18. Type III hypersensitivity diseases
Pathogenesis
Suggested reading
19. Selected type IV hypersensitivities
Cutaneous basophil hypersensitivity
Contact dermatitis
Canine contact dermatitis
Suggested reading
20. Diagnostic assays
In vitro assays
In vivo assays
Suggested reading
21. Allergies in veterinarians
Allergens
Specific environments
Veterinarians
Pathogenesis
Specific immunotherapy
Suggested reading
Abbreviations and acronyms
Index